Taken together our results indicate that IDLV can be harnessed for producing a vaccine able to induce a comprehensive immune response, including functional antibodies directed toward HA and NA proteins present on the vector particles in addition to a functional T cell response directed to the protein transcribed from the vector.Superiore di Sanità, Rome, Italy.lymph nodes draining and not draining the site of primary immunization with National Center for Emerging and Zoonotic Infectious Diseases, Center for Disease Organisation for Animal Health (OIE) Reference Expert and Laboratory for Rabies.Animal Health (OIE) Reference Expert and Laboratory for Rabies.National Center for Emerging and Zoonotic Infectious Diseases, Center for Disease Organisation for Animal Health (OIE) Reference Expert and Laboratory for Rabies.competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. workers from a Guatemalan cancer center.individuals with COVID-19 to be identified, and post-infection and post-vaccination immunity status to be evaluated. OBJECTIVE: To know the behavior of anti-SARS-CoV-2 IgG antibodies before and after vaccination in workers of a cancer center. METHODS: Prior to the application of the vaccine, the presence of anti-SARS-CoV-2 IgG antibodies (n = 171) was analyzed by evaluating anti-N IgG antibodies; post-vaccination, after receiving the second dose, anti-S IgG antibodies were evaluated (n = 60). RESULTS: Prior to Polysucrose 400 , IgG antibodies were present in 18.71% of participants; they were detected in 65.22% of those with prior history of COVID-19 diagnosis and in 11. 49% of those without it. The positions with the highest prevalence were nurses (28.26%), paramedics (27.59%) and administrative workers (27.78%), p < 0.01. Anosmia, ageusia and chest tightness were associated with the presence of IgG (p < 0. 05). Post-vaccination, all participants developed IgG antibodies; people with a previous COVID-19 diagnosis had higher titers: 10,277 vs. 6,819 AU/mL, p < 0.001. CONCLUSIONS: The study of anti-SARS-CoV-2 IgG antibodies allowed asymptomatic health workers to be identified. A high percentage of participants with prior COVID-19 diagnosis had antibodies. All participants developed IgG antibodies after vaccination, with higher titers being identified in those with previous infection. de Cancerología, Guatemala, Guatemala.de Cancerología, Guatemala, Guatemala.de Cancerología, Guatemala, Guatemala.de Cancerología, Guatemala, Guatemala.posvacunación en un centro oncológico de Guatemala.of mice to sheep red blood cells.response of mice to sheep red blood cells (SRBC) was investigated. When splenic memory cells were intravenously inoculated, the greater part of these cells disappeared from the peripheral blood between 30 min and 6 h after injection. Transfer of immune spleen cells 2 days before immunization with 4 X 10(8) SRBC intravenously caused decreased numbers of PFC in the recipient spleen and up to 10 times as many PFC in the bone marrow. Apparently, the regulating influence of immune spleen cells upon antibody formation during the primary response can Institute for Infectious and Inflammatory Diseases (INFINITy), Toulouse 31300, 31000, France; Centre for Epidemiology and Research in Population Health Unit Bretagne, Toulouse 31300 France.Bretagne, Toulouse 31300 France.Bretagne, Toulouse 31300 France.Inflammatory Diseases (INFINITy), Toulouse 31300, France; Infectious and Tropical 31000, France; Centre for Epidemiology and Research in Population Health Unit Institute for Infectious and Inflammatory Diseases (INFINITy), Toulouse 31300, communicable infectious diseases. Thirteen female and 39 male staff were investigated. Antibodies to morbilli, varicella zoster, toxoplasma, cytomegalovirus, hepatitis B, mumps and rubella were determined. Hepatitis B surface antigen tests were also carried out. Twelve males were susceptible to mumps and 10 were subsequently vaccinated. No side effects were noted. Polysucrose 400 Food additive of five females susceptible to rubella requested vaccination and all showed an antibody response without early or delayed side effects. The desirability of offering vaccinations to susceptible adult staff is discussed.
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